YAKUBU A S, AFAR S J, SULAIMAN F, ABUBAKAR A A, ELSA A T, KENE R O C, ONIFADE K I, ADEYANJU J B
047336 YAKUBU A S, AFAR S J, SULAIMAN F, ABUBAKAR A A, ELSA A T, KENE R O C, ONIFADE K I, ADEYANJU J B (eterinary Surgery and Radiology, Univ of Agriculture Makurdi, Benue Nigeria, Email: firstname.lastname@example.org) : Hematological and cardiopulmonary effects of propofol anesthesia in red sokoto goat of Nigeria. Anim Sci Rep 2020, 13(2), 16 - 27.
Propofol is a unique non-barbiturate, non-steroid, short-acting general intravenous anaesthetic agent associated with rapid and smooth induction and rapid recovery. Earlier studies have indicated the adverse effect of propofol anesthesia on hematological parameters, contributing to immune suppression in dog. Propofol has also been reported to cause depression of respiratory function due to reduction of sensitivity of respiratory centre to carbon dioxide and tissue oxygen uptake in goat. The high cost of anesthetic agents, especially general or intravenous anesthetics, lack of technical know-how of endotracheal intubation and paucity of suitable anesthetic agents limits the ability of the surgeon to perform invasive surgery successfully in goats. This study was conducted to evaluate the effects of propofol anesthesia on the hematological and cardiopulmonary parameters in Red Sokoto goats of Nigeria for possible adoption in routine invasive surgical procedures in small ruminants due to non-availability of information on this aspect. Five apparently healthy female Red Sokoto goats weighing between 17-25 kg were used for the study. Propofol was used for induction of anesthesia with 4mg/kg body weight for 10 seconds and maintained at 0.4 mgkg-1min-1 by continuous infusion for 60 minutes. Hematological and cardiopulmonary parameters were recorded before anesthetization (T0) and subsequently at 5 (T5), 10 (T10), 15 (T15), 30 (T30), 45 (T45), and 60 (T60) minutes after anesthetization, and 1 hour post recovery (T120). The mean onset of propofol anaesthesia was found to be 20.6 ? 2.6 seconds. All the animals showed prolapsed third eyelid, whereas the tail, palpebral, deglutition and auricular reflexes were abolished. The goats showed no outward signs of excitement. Endotracheal intubation was difficult. Onset of action was rapid, so also the time of recovery. Hematological parameters in the study included Haematocrit (PCV %) value, Red Blood Cell (RBC) Count, Hemoglobin concentration (Hgb), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC),and White Blood Cell (WBC) Count. Cardiopulmonary parameters included rectal temperature, respiration rate, pulse rate, mean arterial blood pressure (MABP) and oxygen saturation level (SpO2). The result of the present study did not reveal significant (P>0.05) alteration in hematological indices and cardiopulmonary parameters before anesthetization (T0), during anesthesia (T5-T60) and after recovery from anesthesia (T120). It is concluded that induction of propofol anesthesia at 4mg/kg body weight and maintenance at 0.4mg/kg/minute for surgical interventions in Red Sokoto goats triggered rapid onset and smooth perpetuation without detrimental hematological and cardiopulmonary consequences during anesthetization and post-recovery.
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