002347 Ahmadizadeh M;JaffareMoosave S A;Ahmadi A (Toxicology Dep, Public Health School and Physiology Research centre, Jundishspur Unive, Alivaz, Iran, Email: Dr_M_Ahmadizadeh@yahoo.com) : Effect of vitamin C on 3,4-hylenedioxymethamphetamine (MDMA)- induced toxicity in mice liver. Biochem Cell Archs 2008, 8(1), 59-62.
The effect of vitamin C on 3,4-methylenedioxymethamphetamine (MDMA) -induced toxicity in mice liver has been studied. The substance, 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy, is an amphetamine derivative. A long duration of action has led to its widespread popularity among teenagers and young adults in recent years. Increasing evidence indicated that this agent produced hepatotoxicity. The aim of the study was to investigate the effect of vitamin C on ecstasy produced hepatotoxicity. Adult male mice were pretreated with 300 mg/kg vitamin C (vit C). Control group were received vehicle only. 30 min later, animals were given MDMAat doses 0, 10, 20 or 30 mg/kg. 24 h later, animals were killed with over dose of sodium pentobarbital. Blood was collected for determination of ALT, AST and ALP. Liver tissues were removed, fixed and processed for light microscopy Results of the study showed that MDMA produced dose-dependent manner injury in liver cells. Vit C diminished cells against MDMA-induced toxicity. These findings further support the view that ecstasy and/or its metabolite (s) may be responsible for rat liver injury. Vit C has potential to reduce liver cells against MDMA produced hepatotoxicity.
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