003333 GUPTA A, JEYAKUMAR E, LAWRENCE R (Industrial Microbiology Dep, Sam Higginbottom Univ of Agriculture, Prayagraj - 211 007, Uttar Pradesh) : Pyrogallol: A competent therapeutic agent of the future. Asian Jr of Microbiol Biotech Env Sc 2021, Vol 23 (2), 213 - 7.
Pyrogallol is a naturally occurring phenolic compound found to be present in Emblica officinalis (Amla or Indian Gosseberry), Jatropha neopauciflora, tea, coffee, avocado, apricot, etc. Pyrogallol falls in the category of tannins and is also known as 1,2,3-trihydroxy benzene and 1,2,3-benzenetriol. Intake of these kinds of compounds prevents oxidative damage to cell membrane lipid, protein, and nucleic acid due to the strong quenching property of free radicals and may protect against cardiovascular, immune/autoimmune diseases, and brain dysfunctions viz. Parkinson’s, Alzheimer’s, Huntington’s diseases. Also, the puzzle of microbial resistance, which arises due to the uncontrollable use of antimicrobial drugs, can be solved by using these kinds of natural products in the treatment of various maladies. The popularity of these natural products to be used as novel antimicrobial agents is also because of no side effects shown by these compounds. Usually, phenolic compounds are known for their various biological properties such as antibacterial, antioxidant, antifungal, antiviral, antiseptic, anti-dermatitic, cardio protective, anti-mutagenic, pesticide, etc. The present study aims to focus on antibacterial, antifungal, anticancer, and antioxidant properties of pyrogallol as the prolific contributions have been made in the past by various researchers on these properties of pyrogallol. Pyrogallol can be used as a competent therapeutic agent in the future. However, the mechanism of antimicrobial action of pyrogallol is still unknown and needed to be studied. This review article is an endeavor to harmonize the knowledge about the utility of pyrogallol in the extirpation of various ailments.